基本信息

　　姓名: 张东伟

　　Email: zhdw1006@163.com

工作经历

　　2018.01—至今　　　北京中医药大学中医学院　　　研究员

　　2012.06—2017.12 　北京中医药大学基础医学院　　副研究员

　　2012.02—2012.06 　国家食品药品监督管理局高级研修学院

　　2006.10—2011.09 　加拿大不列颠哥伦比亚大学　 博士后、副研究员

　　2004.07-- 2006.10　清华大学化学系 　　　　　　博士后

教育经历

　　2001.9--2004.7 北京中医药大学，博士（生物化学）

　　1998.9--2001.7 河南中医学院，硕士（中药药理学）

　　1993.9--1997.7 河南中医学院，学士（中药学）

教学经历

　　《高级分子生物学实验》、《生物化学》、《中药学》

研究方向

　　[1].代谢性疾病的发病机理和天然药物的防治作用研究；

　　[2].天然产物中小分子的抑制剂研发；.

　　[3].蛋白酶和疾病的关系；

　　[4].药物作用的生化机理和创新药物的研发.

科学研究

　　[1]. 2021年国家自然基金面上项目：基于肠道菌群代谢产物短链脂肪酸驱动骨髓免疫微环境探讨女贞子抗骨质疏松的分子机制和物质基础（82074235），55万元，2021/01-2024/12，在研，主持；

　　[2].2019年国家自然基金面上项目：基于Sema3A/Nrp1/PlexinA1信号通路探讨女贞子抗骨质疏松的分子机制和物质基础（81874373），56万元，2019/01-2022/12；

　　[3].2017年北京市自然基金面上项目：基于Wnt/β-Catenin研究女贞子对去卵巢骨质疏松大鼠的作用机理和物质基础（7172126）, 2017/01-2019/12, 20万；

　　[4].八子补肾方抗衰老的作用机理研究（横向课题），2016/9/30-2018/12/31，68.5万；

　　[5].2013年国家自然基金面上项目：基于中药选择性Cathepsin K活性的抑制剂对骨质疏松的分子机制研究（81273995），2013/01-2016/12, 70万；

学术兼职

　　[1]中国中西医结合学会内分泌专业委员会骨质疏松专家委员会副主任委员（2019—至今）；

　　[2]中国老年学和老年医学学会骨质疏松分会（OSCG）骨内科专业委员会、中医药分会常务委员（2017—至今）；

　　[3]世界中医药学会联合会糖尿病专业委员会理事（2017—至今）；

　　[4]《中国骨质疏松杂志》常委编委（2015—至今）；

　　[5]《医学参考报•骨质疏松频道》青年编委会副主任会员。

发表主要学术论文 (*责任作者, 2015年以来)

　　[1].Li L, Chen B, An T, Zhang H, Xia B, Li R, Zhu R, Tian Y, Wang L, Zhao D, Mo F, Li Y, Yang G, Orekhov AN, Prentki M, Zhang D*, Jiang G*, Zhu X*. BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose and NaNO2. J Ethnopharmacol. 2021 May 10;271:113810.

　　[2].Li L, Chen X, Su C, Wang Q, Li R, Jiao W, Luo H, Tian Y, Tang J, Li X, Liu B*, Wang W*, Zhang D*, Guo S*. Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice. Biomed Pharmacother. 2020;132:110817.

　　[3].Li L+, Li R+, Zhu R, Chen B, Tian Y, Zhang H, Xia B, Jia Q, Wang L, Zhao D, Mo F, Li Y, Zhang S, Gao S, Zhang D*, Guo S*. Salvianolic acid B prevents body weight gain and regulates gut microbiota and LPS/TLR4 signaling pathway in high-fat diet-induced obese mice. Food Funct. 2020 11(10):8743-8756.

　　[4].Liu H, Guo Y, Zhu R, Wang L, Chen B, Tian Y, Li R, Ma R, Jia Q, Zhang H, Xia B, Li Y, Wang X, Zhu X, Zhang R, Brӧmme D, Gao S, Zhang D*, Pei X*. Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats. Phytother Res. 2020 35(1):424-441.

　　[5].Zhu R, Chen B, Bai Y, Miao T, Rui L, Zhang H, Xia B, Li Y, Gao S, Wang XD, Zhang D*. Lycopene in protection against obesity and diabetes: A mechanistic review. Pharmacol Res. 2020;159:104966

　　[6]. Ruyuan Zhu, Junping Wei, Haixia Liu, Chenyue Liu, Lili Wang, Beibei Chen, Lin Li, Qiangqiang Jia, Yimiao Tian, Rui Li, Dandan Zhao, Fangfang Mo, Yu Li, Sihua Gao, Xiang-Dong Wang, Dongwei Zhang*. Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice. The Journal of Nutritional Biochemistry. 2020, 78:108335.

　　[7].Li L, Chen B, Zhu R, Li R, Tian Y, Liu C, Jia Q, Wang L, Tang J, Zhao D, Mo F, Liu Y, Li Y, Orekhov AN, Brömme D, Zhang D*, Gao S*. Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice. Aging (Albany NY). 2019;11(21):9348-9368.

　　[8].Liu C+, Wang L+, Zhu R+, Liu H+, Ma R, Chen B, Li L, Guo Y, Jia Q, Shi S, Zhao D, Mo F, Zhao B, Niu J, Fu M, Orekhov AN, Brömme D, Gao S, Zhang D*. Rehmanniae Radix Preparata suppresses bone loss and increases bone strength through interfering with canonical Wnt/β-catenin signaling pathway in OVX rats. Osteoporos Int. 2019;30(2):491-505.

　　[9].Panwar P, Law S, Jamroz, Azizi P, Zhang D, Ciufolini M, Brömme D*. Tanshinones that selectively block the collagenase activity of cathepsin K provide a novel class of ectosteric antiresorptive agents for bone. Br J Pharmacol. 2018;175(6):902-923.

　　[10].Beibei Chen+, Lili Wang+, Lin Li+, Ruyuan Zhu , Haixia Liu, Chenyue Liu, Rufeng Ma, Qiangqiang Jia, Dandan Zhao, Jianzhao Niu, Min Fu, Sihua Gao, Dongwei Zhang*. Fructus Ligustri Lucidi in Osteoporosis: A Review of its Pharmacology, Phytochemistry, Pharmacokinetics and Safety. Molecules, 2017, 22(9), 1469.

　　[11].Zhu R, Liu H, Liu C, Wang L, Ma R, Chen B, Li L, Niu J, Fu M, Zhang D*, Gao S*. Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety. Pharmacological Research. 2017, 122:78-89.

　　[12].Wang L, Ma R, Guo Y, Sun J, Liu H, Zhu R, Liu C, Li J, Li L, Chen B, Sun L, Tang J, Zhao D, Mo F, Niu J, Jiang G, Fu M, Brömme D, Zhang D*, Gao S. Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-κB Pathway. Frontiers in Pharmacology. 2017,8:266.

　　[13].Wang L, Ma R, Liu C, Liu H, Zhu R, Guo S, Tang M, Li Y, Niu J, Fu M, Gao S*, Zhang D*. Salvia miltiorrhiza: A potential red light to the development of cardiovascular diseases. Current Pharmaceutical Design. 2017, 23(7):1077-1097.

　　[14].Ma R, Wang L, Zhao B, Liu C, Liu H, Zhu R, Chen B, Li L, Zhao D, Mo F, Li Y, Niu J, Jiang G, Fu M, Bromme D, Gao S*, Zhang D*. Diabetes Perturbs Bone Microarchitecture and Bone Strength through Regulation of Sema3A/IGF-1/β-Catenin in Rats. Cell Physiol Biochem. 2017;41(1):55-66.

　　[15].Haixia Liu, Ruyuan Zhu, Chenyue Liu, Rufeng Ma, Lili Wang, Beibei Chen, Lin Li, Jianzhao Niu, Dandan Zhao, Fangfang Mo, Min Fu, Dieter Bromme, Dongwei Zhang*, and Sihua Gao*. Evaluation of Decalcification Techniques for Rat Femurs Using HE and Immunohistochemical Staining. BioMed Research International. 2017; 2017: 9050754.

　　[16].Attané C, Peyot ML, Lussier R, Poursharifi P, Zhao S, Zhang D, Morin J, Pineda M, Wang S, Dumortier O, Ruderman NB, Mitchell GA, Simons B, Madiraju SR, Joly E, Prentki M*. A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice. Diabetologia. 2016, 59(12):2654-2663.

　　[17].Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SR, Prentki M. Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolic control and signaling in pancreatic β–cells and hepatocytes. Proceedings of the National Academy of Sciences. 2016;113(4):E430-9.

　　[18].Rufeng Ma, Ruyuan Zhu, Lili Wang, Yubo Guo, Chenyue Liu, Haixia Liu, Fengwei Liu, Hongjun Li, Yu Li, Min Fu, Dongwei Zhang*. Diabetic osteoporosis: A review of its traditional Chinese medicinal use, clinical and preclinical research. Evid Based Complement Alternat Med. 2016; 2016:3218313.

　　[19].Yubo Guo, Lili Wang, Rufeng Ma, Qianqian Mu, Na Yu, Yi Zhang, Yuqing Tang, Yu Li, Guangjian Jiang, Dandan Zhao, Fangfang Mo, Sihua Gao*, Meijuan Yang, Feifei Kan, Qun Ma, Min Fu, Dongwei Zhang*. JiangTang XiaoKe granule attenuates cathepsin K expression and improves IGF-1 expression in the bone of high fat diet induced KK-Ay diabetic mice. Life Sciences. 2016, 148: 24-30.

　　[20].Lili Wang, Yu Li, Yubo Guo, Rufeng Ma, Min Fu, Jianzhao Niu, Sihua Gao, Dongwei Zhang*. Herba Epimedii: An ancient Chinese herbal medicine in the prevention and treatment of osteoporosis. Current Pharmaceutical Design. 2016, 22(3):328-49.

　　[21].Fu XY, Zhang DW#, Li YD, Zhao PW, Tang YQ, Niu JZ, Li Y*. Curcumin Treatment Suppresses CCR7 Expression and the Differentiation and Migration of Human Circulating Fibrocytes. Cell Physiol Biochem. 2015;35(2):489-98.