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硕士研究生招生导师

张毅

作者:基础医学院    发布日期:2014年09月20日

  

  1. 姓名:张毅。 性别:男。 出生年月:1978年5月。

  学习及工作经历:2009年7月博士研究生毕业于北京大学医学部,2009年7月于北京中医药大学基础医学院参加工作。

  2. 职务:无。 职称:副教授。 社会兼职:无。

  3. 招生专业:中西医结合基础。

   

  研究方向:中医药治疗帕金森病的机制研究

  4. 承担课题(2009-2014)

  (1)国家自然科学基金,基于DJ-1调控的PI3K/AKT信号途径探讨大补阴丸对帕金森病中线粒体功能的保护作用。

  (2)教育部博士学科点专项基金,知母宁保护帕金森病中线粒体功能与DJ-1调控的PI3K/AKT信号途径之间相关性的研究。

  (3)校级课题,帕金森病Parkin基因易感突变点Meta分析的研究。

  5. 研究成果

  发表SCI文章多篇。

  (1)Zhang Y, Wang ZZ, Sun HM, Li P, Li YF, Chen NH (2014) Systematic review of traditional Chinese medicines for depression in Parkinson’s disease. American Journal of Chinese Medicine, 32: x1-x17.

  (2)Zhang Y, Sun HM, He X, Wang YY, Gao YS, Wu HX, Xu H, Gong XG, Guo ZY (2013) Da-Bu-Yin-Wan and Qian-Zheng-San, two traditional Chinese herbal formulas, up-regulate the expression of mitochondrial subunit NADH dehydrogenase 1 synergistically in the mice model of Parkinson's disease. Journal of Ethnopharmacology 146: 363-371.

  (3)Zhang Y, Wang ZZ, Sun HM (2013) A meta-analysis of the relationship of the Parkin p.Val380Leu polymorphism to Parkinson's disease. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162B: 235-244.

  (4)Wang ZZ, Zhang Y, Liu YQ, Zhao N, Zhang YZ, Yuan L, An L, Li J, Wang XY, Qin JJ, Wilson SP, O'Donnell JM, Zhang HT, Li YF (2013) RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects. British Journal of Pharmacology 168: 1001-1014.

  (5)Zhang Y, Wang ZZ, Sun HM (2012) Meta-analysis of the influence of Parkin p.Asp394Asn variant on the susceptibility of Parkinson's disease. Neuroscience Letters 524: 60-64.

  (6)Zhang Y, Wang ZZ, Sun HM (2012) Lack of association between p.Ser167Asn variant of Parkin and Parkinson's disease: A meta-analysis of 15 studies involving 2280 cases and 2459 controls. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B: 38-47.

  (7)Wang ZZ, Zhang Y, Yuan YH, Chen NH (2012) Developmental expression of chemokine-like factor 1, a novel member of chemokines family, in postnatal rat cerebral cortex. Neuroscience Letters 519: 51-55.

  (8)Zhang Y, Li PP (2011) Assessment of shikonin for potential estrogenic activity by dual-luciferase reporter based bioluminescent measurements in vitro. Pharmazie 66: 141-143.

  (更新时间:2014年7月)